This study aims to improve the estimates of the economic impacts of climate change by developing a river flood risk model CLIMRISK-RIVER and introducing it into an existing climate-economy integrated assessment model (IAM). It operates on a local scale and can project climate change-related river flood damage for various socioeconomic, climate and flood adaptation scenarios. Whereas other IAMs have relied on temperature as a climate change proxy, we show that precipitation is a key variable in projecting river flood damage. The way adaptation is accounted for in our flood damage functions has a large influence on the results, highlighting the relevance of modelling local level adaptation in IAMs. Results presented at different spatial scales demonstrate the relevance of river flood damage functions for estimating the economic impacts of climate change and allows for exploration of the spatial distribution of impacts through local estimates.