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This document reviews the viral, genetic and immune factors that contributed to the severity of the 1918 pandemic and discusses the implications for modern pandemic preparedness. It addresses unresolved questions of why the 1918 influenza H1N1 virus was more virulent than other influenza pandemics and why some people survived the 1918 pandemic and other…
This guidance can be used to inform and harmonize national and international pandemic preparedness and response. Countries should consider reviewing and/or updating national influenza preparedness and response plans to reflect the approach taken in this guidance. Also articulated are the roles and responsibilities of WHO relevant to pandemic preparednes…
This report describes decision-support tools, including models and nonmodeling approaches, that are relevant to infectious disease prevention, detection, and response and aligns these tools with real-world policy questions that the tools can help address. The intended audience includes technical experts — for example, modelers and subject-matter expert…
The goal of this framework is to provide an overview of how RCCE resources and activities need to be prepared for across different response pillars among provinces and countries neighbouring North Kivu, Democratic Republic of Congo.  The purpose of proactively carrying out RCCE activities along with other activities essential for an Ebola outbreak…
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This study highlights some promising classes of technologies, including an assessment of their potential relevance to reducing pandemic and global catastrophic biological risks. The report seeks to Pinpoint areas of need for technological solutions to address severe pandemics and GCB events; Identify technologies that have significant potentia…
This study was conducted to review eight major natural disasters in Indonesia that were followed by outbreaks of infectious disease. Results emphasize the importance of integrated health education in schools and community-based disaster risk reduction (DRR) plans, including information dissemination, to create resilient communities. Water-borne and air-…
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A WHO guideline for emergency risk communication (ERC) policy and practice These guidelines provide overarching, evidence-based guidance on how risk communication should be practised in an emergency. The recommendations also guide countries on building capacity for communicating risk during health emergencies. Recent public health emergencies, such as…
The main objective of this report was to identify lessons learned from the preparedness and detection phase to the end of second wave of the cholera epidemic in Yemen to better prepare for future outbreaks in Yemen and similar contexts. In 2015, the United Nations declared Yemen a Level 3 emergency. On September 28, 2016, a large-scale cholera outbreak…
Due to the importance of managing communicable diseases (CD) in disaster situations, the Center for Communicable Diseases Management (CCDM) within the Ministry of Health and Medical Education, Islamic Republic of Iran, has taken measures to improve routine communicable diseases management systems in normal and emergency situation.  This study aims…
This study estimates the minimum cost for achieving vaccine research and development preparedness targets in a portfolio of 11 epidemic infectious diseases, accounting for vaccine pipeline constraints and uncertainty in research and development preparedness outcomes.  The study finds that the cost of developing a single epidemic infectious disease…
JRC is developing a unified global system for public health threat detection and risk assessment (EIOS), and it is the technical and scientific leader of the Index for Risk Management (INFORM), a composite indicator that identifies countries at risk of humanitarian crisis and disaster that would overwhelm national response capacity. Both projects are in…
This report summarizes workshop discussions that aimed to review best practice in the areas of emergency preparedness and risk communication, specifically in the context of public health preparedness plans. This report includes sections on foundational theory, case studies on past health emergencies, and key challenges to emergency risk commun…
This report provides an objective, evidence-based monitoring framework to track the performance of the international community and its key institutions in reducing a substantial global threat of disease outbreaks, and to regularly disseminate the results. This will help to clarify and increase accountability. Work is already underway to improve global h…

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