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This document reviews the viral, genetic and immune factors that contributed to the severity of the 1918 pandemic and discusses the implications for modern pandemic preparedness. It addresses unresolved questions of why the 1918 influenza H1N1 virus was more virulent than other influenza pandemics and why some people survived the 1918 pandemic and other…
This Operational Framework provides a practical reference toward achieving the aim of public health systems resilience and preparedness at the human-animal-environment interface, with the following key objectives: Provide operational guidance to directly address the need for targeted investments that prevent, prepare, detect, respond to and reco…
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This issue brief provides an overview of the health impacts of climate change in the U.S. state of Virginia. The brief includes a discussion of heat, coastal flooding, water- and food-borne illnesses, air quality, and vector-borne diseases. Climate change is altering seasonal patterns, making our summers hotter, and fueling increased flooding…
This guidance can be used to inform and harmonize national and international pandemic preparedness and response. Countries should consider reviewing and/or updating national influenza preparedness and response plans to reflect the approach taken in this guidance. Also articulated are the roles and responsibilities of WHO relevant to pandemic preparednes…
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In order to further explore and identify priority areas for action for strengthening One Health preparedness in Europe, ECDC convened an expert consultation on 11–12 December 2017. The consultation consisted of both plenary and parallel group work sessions. The latter focused in particular on addressing three key questions: Based on the key risk driv…
The World Bank and the Coalition for Epidemic Preparedness Innovations (CEPI) established the International Vaccines Task Force on Strengthening Country Capacity for Vaccines Research and Development (Task Force) in October 2017 to develop a set of recommendations on strategic investments that can strengthen clinical research and clinical tria…
This report describes decision-support tools, including models and nonmodeling approaches, that are relevant to infectious disease prevention, detection, and response and aligns these tools with real-world policy questions that the tools can help address. The intended audience includes technical experts — for example, modelers and subject-matter expert…
Clade X is a pandemic tabletop exercise hosted by the Johns Hopkins Center for Health Security in May 2018 to identify important policy issues and preparedness challenges that could be solved with sufficient political will and attention. The Center designed the Clade X scenario by mixing aspects of actual past events with well-researched fictional eleme…
Migrant centres, as other institutions hosting closed or semi-open communities, may face specific challenges in preventing and controlling communicable disease transmission, particularly during times of large sudden influx. However, there is dearth of evidence on how to prioritise investments in aspects such as human resources, medicines and vaccines, s…
This document provides a regional assessment of food security and vulnerability for SADC member countries, and aims to synthesise national level vulnerability assessments, facilitate discussions and a shared vision for reducing vulnerability, and discuss emerging trends in vulnerability assessments.  This document describes the regional food and n…
The goal of this framework is to provide an overview of how RCCE resources and activities need to be prepared for across different response pillars among provinces and countries neighbouring North Kivu, Democratic Republic of Congo.  The purpose of proactively carrying out RCCE activities along with other activities essential for an Ebola outbreak…
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This study highlights some promising classes of technologies, including an assessment of their potential relevance to reducing pandemic and global catastrophic biological risks. The report seeks to Pinpoint areas of need for technological solutions to address severe pandemics and GCB events; Identify technologies that have significant potentia…
This study was conducted to review eight major natural disasters in Indonesia that were followed by outbreaks of infectious disease. Results emphasize the importance of integrated health education in schools and community-based disaster risk reduction (DRR) plans, including information dissemination, to create resilient communities. Water-borne and air-…
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A practical guide and tool for planning, conducting and evaluating simulation exercises for outbreaks and public health emergency preparedness and response This exercise manual has been designed to meet the needs of WHO, its Member States and its partners to support and develop exercise practitioners’ competency to plan, implement and evaluate simulati…
For the past decade, the Asia Pacific Strategy for Emerging Diseases (APSED) has provided a common framework for action in the Asia Pacific region for strengthening the core capacities required under IHR (2005). Results from the evaluation of APSED implementation conducted in 2015 confirmed that Member States viewed APSED as an important and relevant st…

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